Cell Therapy ‘99: Introduction

Immune ablation and stem-cell therapy in autoimmune disease: Introduction

Estimates of the prevalence of autoimmune diseases range from 3 to 7%, and the treatment of a minority of these patients with severe progressive disease is not satisfactory. It has been recognized that the autoimmune basis of human disease results from the failure of multiple components of the immune system, but the most frequently used criteria to establish the autoimmune nature of a disease i...

Introduction: anti-adhesion therapy in sickle cell disease.

In this issue of Blood, Kaul et al1 report that stimulation by platelet-activating factor (PAF) of artificially perfused rat mesocecum ex vivo promotes the adhesion of human sickle red blood cells (SS RBC) to postcapillary endothelium. Notably, this adhesive interaction was blocked by two different monoclonal antibodies (MoAbs) to endothelial aVb3 integrin receptor, with resulting improvement i...

99 4 Chapter One INTRODUCTION AND MOTIVATION

: ANSW _ 1 / FEB 99 2 Introduction

Cell Therapy in Cardiovascular Disease

  Recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. Earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. In this regard the Royan cell therapy center designed a few trials in collaborat...